Wales defender Ethan Ampadu said on Thursday that Wales want to prove "how good they are" as they return to the World Cup for the first time since 1958.
Manager Rob Page's side will end Wales' 64-year wait for a game in football's biggest showpiece. Plays USA in Group B on Monday.
"We have a great responsibility and we all know that," said Ampadu. “We want to show how big Wales can be as a country and show how good we are. I think we have to have this mentality, aim for victory. We are not here to draw or lose."
Wales qualified for the World Cup after beating Ukraine 1-0 in the play-off final and in Qatar will be hoping to emulate the John Charles-inspired side who reached the quarter-finals before losing to Pele's Brazil.
"We are here to play. We are here to do the best we can and if it gives us an opportunity to win it, then of course we will. We will back ourselves and we don't care who the other favorites are," said Ampadu, who is currently on loan at Spezia in Serie A from Chelsea.
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The clash with neighbors England closes the group stage for Wales, who have progressed to the knockout stage in the last two European Championships. Wales will also have work to do with Iran in the group.
"We're on the biggest stage and we just want to perform well and go as far as we can," winger Mark Harris said. "We have to play all three games with maximum commitment and of course we have to win them. We will enter only for victory, I don't think it matters much in what order the games are in".
Midfielder Joe Allen has been in the "race" to prepare to face the Americans, while captain Gareth Bale is in good form. Bale in recent months has been spared by his MLS team, Los Angeles FC.
Ampadu said that "everyone is in good shape and motivated to go far". Wales have postponed training sessions to 16pm Doha time in an attempt to avoid the heat in Qatar. Harris admitted it had been a shock to the training system, but added that none of the teams in the group will have an advantage when it comes to the heat.
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"We went for a walk in the morning around 11 and it was really warm so we were sweating just walking around the hotel," he said. "Obviously we're not used to it, but I wouldn't say it's scary or anything. I am sure that training during the next few days will help a lot to be ready to face this obstacle as well".
In addition to Bale, in Wales they rely heavily on the midfielder with great experience in European football, Aaron Ramsey. After Arsenal and Juventus, Ramsey is playing in France this season at Nice.