Benjamin Netanyahu has insisted again that Israel must maintain security control over all Palestinian territories.
The Israeli prime minister said this condition was "contrary" to the creation of a future Palestinian state.
His comments on Saturday contradicted the pressure the US and others are putting on his government to commit to future Palestinian statehood.
Netanyahu and US President Joe Biden discussed the future of the Palestinian territories in a phone call on Friday.
The Israeli prime minister's latest intervention appeared to deepen a public rift between his government and the US over the future governance of Gaza and the West Bank when the conflict ends.
The US believes that a future Palestinian state alongside Israel - known as the "two-state solution" - is vital to long-term stability. But the White House acknowledged this week that the US and Israeli governments "clearly see things differently."
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Shortly before UN vote, Netanyahu insists on no Palestinian state
Speaking to reporters after the two leaders spoke on the phone for the first time in almost a month, Biden insisted a two-state solution was still possible with Mr Netanyahu in office.
“There are a number of types of two-state solutions. There are a number of countries that are members of the UN that... do not have their own armies," he said.
But on Saturday, Netanyahu doubled down on his position, which he has held for most of his political career and reiterated earlier this week.